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Cadasil - Case 1

A 47 year-old man presented with several strokes over five years leaving him with permanent deficits of speech, coordination and strength on both sides of his body.

Flair MRI axial scans. Note the prominent white matter changes. This represented the confluence of many small vessel strokes. A similar MRI picture could be seen in advanced multiple sclerosis or an inherited disorder of white matter (i.e., leukodystrophy). In this patient, his strokes were due to a rare condition, Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Cadasil is a familial non-arteriosclerotic, non-amyloid arteriopathy which presents with recurrent subcortical ischemic strokes starting in middle age. The disease has been mapped to chromosome 19q12.

Revised 09/25/05.
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