Dementia - Alzheimer's

A 58 year old man developed dementia consistent with Alzheimer's disease.

Show the Enlarged Sylvian Fissures     Show the Enlarged Temporal Horns     Show the Enlarged Lateral Ventricles     Compare Brain Volumes  

The two images were taken 2 years apart. They show generalized parenchymal volume loss, which is more marked in the second image. Note that since the brain volume is less, the volume of the CSF spaces becomes compensatorily larger. Also note that the volume loss is somewhat asymmetrical, which correlates with the patient's clinical course. In addition to progressive dementia, he developed marked word finding difficulties and an expressive aphasia.Also note the loss of hippocampal volumes which correlates with declining memory function.

Revised 04/19/06.
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