A 58 year old man developed dementia consistent with Alzheimer's disease.
The two images were taken 2 years apart. They show generalized parenchymal volume loss, which is more marked in the second image. Note that since the brain volume is less, the volume of the CSF spaces becomes compensatorily larger. Also note that the volume loss is somewhat asymmetrical, which correlates with the patient's clinical course. In addition to progressive dementia, he developed marked word finding difficulties and an expressive aphasia.Also note the loss of hippocampal volumes which correlates with declining memory function.
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