Neuroscience Clerkship

 

 

Significance of Focal Onset vs. Generalized Onset Seizures

Determining whether a seizure has a focal or generalized onset is often important both for diagnostic and therapeutic purposes.


Focal Seizures imply that the seizure begins in a certain area of the brain, which is often manifested by activity of the functions that area controls. Focal seizures may or may not generalize. The focality of the seizure more often implies a structural problem such as an arteriovenous malformation, stroke or tumor.

Primary Generalized Seizures involve the entire brain and loss of consciousness always occurs. Most often, generalized seizures are inherited, metabolic, toxic or drug-induced.


Signs and Symptoms Suggesting Focal Onset
 

Any aura (olfactory, gustatory, emotional)

Shaking of one limb or side of the body

Sensory symptoms of one limb or side of the body

Lateral eye deviation

Lateral neck deviation

Any focal neurologic sign in the post-ictal state


Common Causes of Focal Onset Seizures


Mesial temporal sclerosis (? birth injury vs congenital)

Head trauma

Stroke

Arteriovenous malformation

Tumor

Subarachnoid hemorrhage

Meningitis

Encephalitis


Common Causes of Generalized Onset Seizures

Inherited (primary generalized epilepsy)

Metabolic derangement

Uremia

Hepatic encephalopathy

Drug Overdose

Drug withdrawal

Hyperthermia (usually in children)